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Health Advisory Lifted for Pittsburg and Antioch

Last updated: 5:39 a.m. Friday, March 27, 2015

The health advisory for Pittsburg and Antioch has been lifted. The advisory was issued for people with respiratory sensitivities this morning after a chemical release at Dow Chemical in Pittsburg. Contra Costa HazMat staff are investigating the incident. More information will be posted as it becomes available.

Viral Hemorrhagic Fevers


Etiologic Agents

Arenaviradae (Lassa, Junin, Machupo, Guanarito, and Sabia), Filoviradae (Marburg and Ebola), Bunyaviradae (Congo-Crimean hemorrhagic fever virus and hantaviruses)and Flaviradae (yellow fever and Dengue) can all cause viral hemorrhagic fever (VHF)


Epidemiology

  • Highly infectious after aerosolization
  • Infectious dose can be as low as 1-10 organisms
  • Risk of person-to-person transmission depends on virus

Clinical

  • Incubation period is 4 - 21 days, depending on virus
  • Clinical presentation would vary by viral agent; however, dominant clinical features of all are a consequence of microvascular damage and changes in vascular permeability. Fever, myalgia, and prostration may evolve to shock, generalized mucous membrane hemmorhage, and neurologic, hematopoietic, or pulmonary involvement.

Laboratory Diagnosis

  • Viral isolation should be handled in a Biosafety Level 3 or 4 facility and may take 3 - 10 days
  • ELISA or reverse transcriptase PCR available for most VHF viruses

Patient Isolation

Isolation room with contact precautions.


Treatment

Ribavirin (30 mg/kg IV × 1, then 15 mg/kg IV q 6 h × 4 days, 7.5 mg/kg IV q 8 × 6 days) may be helpful for Congo-Crimean hemorrhagic fever or arenaviruses


Prophylaxis

Licensed vaccine available only for yellow fever


Thanks to Santa Clara County for information provided on this page.


´╗┐Physicians who need to report a suspected public health emergency should contact the Public Health division immediately at 925-313-6740; or after hours, call the sheriff's dispatch at 925-646-2441 and ask for the Health Officer On Call.

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